CENTURY. Center for Nicotine & Tobacco Use Research at Yale.
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CENTURY
Yale University
School of Medicine
SAC-203
Connecticut
Mental Health Center
34 Park Street
New Haven, CT 06519

Phone:
203-974-7591

Fax:
203-974-7594

E-mail:
infocentury@yale.edu

CENTURY/TTURC Published Studies

 

Published:

Baker, T.B., Hatsukami, D.K., Lerman C., O'Malley S.S., Shields, A.E., & Fiore M.C. (2003). Transdisciplinary science applied to the evaluation of treatments for tobacco use. Nicotine and Tobacco Research, 5(Supplement 1): p. S89-S99.

Brunzell, D.H., Russell, D.S. & Picciotto, M.R. (2003). In vivo nicotine treatment regulates mesocorticolimbic CREB and extracellular regulated kinase signaling in C57B1/6J mice. Journal of Neurochemistry, 84: 1431-1441.

Caldarone, B.J., George T.P., Zachariou, V. & Picciotto, M.R. (2000). Gender differences in learned helplessness behavior are influenced by genetic background. Pharmacol. Biochem. Behav., 66(4): 811-7.

Caldarone, B.J., Duman, C.H. & Picciotto, M.R. (2000). Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain. Neuropharmacology, 39(13): 2779-84.

Caldarone, B.J., Karthigeyan, K., Harrist, A., Hunsberger, J.G., Wittmack, E., King, S.L., Jatlow, P., & Picciotto, M.R. (2003). Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice. Psychopharmacology, 170:94-101.

Cooney, J.L., Cooney, N.L., Pilkey, D.T., Kranzler, H.R., & Oncken, C.A. (2003). Effect of nicotine deprivation on urges to drink and smoke in alcoholic smokers. Addiction, 98:913-921.

Dudas, M.M., Sacco, K.A., & George, T.P. (2003). Psychopharmacological treatments for nicotine addiction in schizophrenia. Essential Psychopharmacology, 5(3):171-184.

Falba, T., Jofre-Bonet, M., Busch, S., Duchovny, N., & Sindelar, J. (2004). Reduction of quantity smoked predicts future cessation among older smokers. Addiction , 99: 93-102.

Fujita, M., Seibyl, J., Vaupel, D., Tamagnan, G., Early, M., Zoghbi, S., Baldwin, R., Horti, A., Koren, A., Mukhin, A., Khan, S., Bozkurt, A. , Kimes, A, London, E., & Innis, R. Whole body biodistribution, radiation-absorbed dose and brain SPET imaging with [123I]5-I-A-85830 in healthy human subjects. (2002). European Journal of Nuclear Medicine, 29:183-190.

Fujita, M., Ichise, M., van Dyck, C.H., Zoghbi, S.S., Tamagnan,G., Mukhin, A.G., Bozkurt, A., Seneca, N., Tipre, D., DeNucci1, C.C., Iida, H., Vaupel, D.B., Horti, A.G., Koren, A.O., Kimes, A.S., London, E.D., Seibyl, J.P., Baldwin, R.M., & Innis, R.B. (2003). Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 30, No. 12.

Fujita M, Al-Tikriti, M.S., Tamagnan, G., Zoghbi, S.S., Bozkurt, A., Baldwin, R.M., & Innis, R.B. (2003). Influence of acetylcholine levels on the binding of a SPECT nicotinic acetylcholine receptor ligand [123I]5-I-A-85380. Synapse, 48(3): 116-22.

George, T.P., & O'Malley, S.S., (2004). Current pharmacological treatments for nicotine dependence. TRENDS in Pharmacological Sciences, 25(1):42-8.

George, T.P., Verrico, C.D., Picciotto, M.R., & Roth, R.H., (2000). Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization. Journal of Pharmacology and Experimental Therapeutics, 295(1): 58-66.

George, T.P., Vessicchio, J.C., Termine, A., Sahady, D.M., Head, C.A., Pepper, W.T., Kosten, T.R. & Wexler, B.E. (2002). Effects of smoking abstinence on visuospatial working memory function in schizophrenia. Neuropsychopharmacology, 26: 75-85

George, T.P., Vessicchio, J.C., Termine, A., Bregartner, T.A., Feingold, A., Rounsaville, B.J., & Kosten, T.R. (2002). A placebo-controlled trial of bupropion for smoking cessation in schizophrenia. Biological Psychiatry, 52: 53-61.

George, T. P., Vessicchio, J.C. (2002). Treating tobacco addiction in schizophrenia: Where do we go from here? (commentary). Addiction, 97: 795-796.

George, T.P., Seyal, A.S., Dolan, S.L., Dudas, M.M., Termine, A., Vessicchio, J.C. (2002). Smoking and schizophrenia: An approach to assessment and treatment. Primary Psychiatry, 9(11): 48-53.

George, T.P., Vessicchio, J.C., Termine, A. (2003). Nicotine and tobacco use in schizophrenia. In: Medical Illness in Schizophrenia (eds: Meyer, J.M. and Nasrallah, H.A.), American Psychiatric Press, Inc., Washington, D.C., pp.81-98.

George, T.P., Vessicchio, J.C., Termine, A., Jatlow, P.I., Kosten, T.R., & O'Malley, S.S. (2003). A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessation. Biological Psychiatry, 53:136-143

George, T.P., Picciotto, M.R., Verrico, C.D., & Roth, R.H. (2001). Effects of nicotine pre-treatment on dopaminergic and behavioral responses to conditioned fear stress in rats: Dissociation of biochemical and behavioral effects. Biological Psychiatry, 49(3): 300-306.

George, T.P. (2002). Addiction in the 21st century: New problems, novel approaches, innovative treatments (guest editorial). Psychiatric Times, 19(2): 45.

Grady, S.R., Meinerz, N.M., Cao, J., Reynolds, A., Picciotto, M.R., Changeux, J.-P., McIntosh, M.J., Marks, M.J. and Collins, A.C. (2001). Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. Journal of Neurochemistry, 76: 258-68.

Jamner, L., Whalen, C., Loughlin, S., Mermelstein, R., Audrain-McGovern, J., Krishnan-Sarin, S., Worden, J., Leslie, F. (2003). Tobacco use across the formative years: A road map to developmental vulnerabilities. Nicotine and Tobacco Research, 5 Suppl 1: S71-8.

Jatlow, P., McKee, S., O'Malley, S. S. (2003). Correction of urine cotinine concentrations for cotinine excretion: Is it useful? Clinical Chemistry, 49: 1932-1934.

King, S.L., Marks, M.J., Grady, S.R., Caldarone, B.J., Koren, A.O., Mukhin, A.G., Collins, A.C. & Picciotto, M.R. Conditional expression in corticothalamic efferents reveals a developmental role for nAChRs in modulation of passive avoidance behavior. Journal of Neuroscience, 23(9): 3837-3843.

Krishnan-Sarin, S., Meandzija B. & O'Malley, S. (2003). Naltrexone and nicotine patch in smoking cessation: A preliminary study. Nicotine and Tobacco Research, 5:851-857.

Marks, M.J., Stitzel, J.A., Grady, S.R., Picciotto, M.R., Changeux, J.-P. & Collins, A.C. (2000) Nicotinic-agonist stimulated 86Rb+ and [3H]epibatidine binding of mice differing in b2 genotype. Neuropharmacology, 39(13): 2632-45.

Mukhin, A.G., Gundisch, D., Horti, A.G., Koren, A.O., Tamagnan, G., Kimes, A.S., Chambers, J., Vaupel, D.B., King, S.L., Picciotto, M.R., Innis, R. & London, E.D. (2000). 5-iodo-A-85380, & a4ß2 subtype-selective ligand for nicotinic acetylcholine receptors. Molecular Pharmacology, 57: 642-649.

McKee, S. A., Wall, A-M, Hinson, R. E. (2003). Effects of an implicit mood prime on the accessibility of smoking expectancies in college females. Psychology of Addictive Behaviors, Vol. 17, No. 3, 219-225.

McKee, S. A., Maciejewski, P. K., Falba, T. & Mazure, C. M. (2003). Sex differences in the effects of stressful life events on changes in smoking status. Addiction, 98: 847-855.

Nash, J., Collins, B., Loughlin, S., Solbrig, M., Harvey, R., Krishnan-Sarin, S., Unger, J., Miner, C., Rukstalis, M., Shenassa, E., Dube, C., Spirito, A. (2003). Training the transdisciplinary scientist: A general framework applied to tobacco use behavior. Nicotine and Tobacco Research, 5 Suppl 1: S41-53.

Olausson, P., Jentsch, J. D. & Taylor, J. R. (2003). Repeated nicotine exposure enhances reward-related learning in the rat. Neuropsychopharmacology, 28(7): 1264-71.

Owens, J.C., Balogh, S.A., McClure-Begley, T.D., Labarca, C., Lester, H.A., Picciotto, M.R., Wehner, J.M. & Collins, A.C. (2003) a4b2*-type neuronal nicotinic receptors modulate the effects of nicotine and ethanol on the acoustic startle response. Alcoholism Clinical and Experimental Research, 27(12):1867-75.

Olausson, P. J., Jentsch, D., Taylor, J.R. (2004). Nicotine enhances responding with conditioned reinforcement. Psychopharmacology, 171:173-178

Oncken, C., Prestwood, K., Cooney, J.L., Unson, C., Fall, P., Kulldorff, M., & Raisz, L. (2002). Effects of smoking cessation or reduction on hormone profiles and bone turnover in postmenopausal women. Nicotine & Tobacco Research, 4: 451- 458.

Oncken C.A., Kranzler, H., O'Malley, P., Gendreau, P., Campbell, W.A. The effect of cigarette smoking on fetal heart rate characteristics. Obstetrics and Gynecology, 2002;99:751-5.

Oncken, C.A., Henry, K.M., Campbell, W.A., Kuhn, C.M., Slotkin, T.A., Kranzler, H.R. The effect of maternal smoking on fetal catecholamine concentrations at birth. Pediatric Research, 2003;53:119-124.

Oncken, C.A., Kranzler, H.R. Pharmacotherapy for smoking cessation during pregnancy. Drug and Alcohol Review 2003;22: 191-202.

Petry, N.M., Oncken, C. Cigarette smoking is associated with increased severity gambling problems in treatment-seeking pathological gamblers. Addiction 2002;97:745-53.

Picciotto, M.R. & Corrigall, W.A. (2002). Neuronal systems underlying behaviors related to nicotine addiction: Neural Circuits and Molecular Genetics. Journal of Neuroscience, 22(9): 3338-41.

Picciotto, M.R., Brunzell, D.H., Zachariou, V., Stevens, T.R., King, S.L. & Caldarone, B.J. (2001). Nicotinic acetylcholine receptor knockout mice: Physiological and behavioral phenotypes and possible clinical implications. Pharmacology and Therapeutics, 92:89-108.

Picciotto, M.R., Brunzell, D.H., & Caldarone, B.J. (2002). Effect of nicotine and nicotine receptors on anxiety and depression. Neuroreport, 13(9): 1097-106.

Picciotto, M.R. (2003). Nicotine as a modulator of behavior: beyond the inverted U. TRENDS in Pharmacological Sciences, 24: 493-499.

Picciotto, M.R. & Zoli, M. (2002). Nicotinic receptors in dementia and aging. Journal of Neurobiology, 53(4): 641-655.

Picciotto, M.R., Caldarone, B.J., King, S.L. & Zachariou, V. (2000). Nicotinic receptors in the brain: links between molecular biology and behavior. Neuropsychopharmacology, 22:451-65.

Picciotto, M.R., Brunzell, D.H., Zachariou, V., Stevens, T.R., King, S.L. and Caldarone, B.J. (2001). Nicotinic acetylcholine receptor knockout mice: Physiological and behavioral phenotypes and possible clinical implications. Pharmacology and Therapeutics, 92:89-108.

 

 

 


Picciotto, M.R, Alreja, M. and Jentsch, J.D. (2002). Acetylcholine. In: K.L. Davis, D. Charney, J.T. Coyle and C. Nemeroff, eds. Psychopharmacology: The Fifth Generation of Progress. Philadelphia: Lippincott, Williams & Wilkins, pp. 3-14.

Price, T.B., Krishnan-Sarin, S., & Rothman, D.L. Smoking impairs muscle recovery from exercise. (2003). Am J Physiol Endocrinol Metab, 285: E116-E122.

Staley, J., Krishnan-Sarin, S., Zoghbi, S., Tamagnan, G., Fujita, M., Seibyl, J., Maciejewski, P., O'Malley, S., Innis, R. (2001). Sex differences in [123I]ß-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse, 41:275-284.

Stevens, T.R., Krueger, S.R., Fitzsimonds, R.M. and Picciotto, M.R. (2003) Mechanism of cortical neuroprotection by nicotine involves activation of calcineurin and inactivation of L-type channels. J Neurosci, 23(31):10093-9.

Vessicchio, J.C., Termine, A. & George, T.P. (2002). Smoking abstinence and panic attacks. Journal of Clinical Psychiatry, 63(7): 594-595.

Whiteaker, P. Marks, M., Grady, S.R., Lu, Y., Picciotto, M.R., Changeux, J.-P. & Collins, A.C. (2000). Pharmacological and null mutation approaches reveal nicotinic receptor diversity. European Journal of Pharmacology, 393: 123-35.

Zachariou, V., Calderone, B.J., Weathers-Lowin, A., George, T.P., Elsworth, J.D., Roth, R.H., Changeux, J.P., & Picciotto, M. (2001). Nicotine receptor inactivation decreases sensitivity to cocaine. Neuropsychopharmacology, 24:576-589.

Zoghbi, S., Tamagnan, G., Fujita, M., Baldwin, R.M., Amici, L., Tikriti, M.A., Amici, L., Seibyl, J., Innis, R. (2001). Measurement of plasma metabolites of (S)-5-[123I]iodo-3-(2-azetidinylmethoxy)pyridine (5-IA-85380), a nicotinic acetylcholine receptor imaging agent, in nonhuman primates. (2001) Nuclear Medicine and Biology, 28:91-96.

(Note: The Yale TTURC grant number is P50-DA-13334. However, some Yale TTURC papers also appear under grant number P50-DA-84733, which is no longer being used.)


In Press:

Balogh, S.A. , Keller, J.J., Picciotto, M.R., Paylor, R., Booker, T.K., Beaudet, A., Heinemann, S. & Wehner, J.M. (2004). Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience, under revision.

Dolan, S.L., Sacco, K.A., Termine, A., Seyal, A.S., Dudas, M.M., Vessicchio, J.C., Wexler, B.E., George, T.P. (2004). Neuropsychological Deficits are Associated with Smoking Cessation Treatment Failure in Patients with Schizophrenia. Schizophrenia Research, in press.

Dudas, M.M., George, T.P. (2004). Non-nicotine Pharmacotherapies for Nicotine Dependence. Essential Psychopharmacology, in press.

Duhig, A. M., Cavallo, D. A., McKee, S. A., & Krishnan-Sarin, S. Daily patterns of alcohol, cigarette and marijuana use in adolescent smokers and nonsmokers. Addictive Behaviors, in press.

Jacobsen, L.K., Souza, D.C., Mencl, W.E., Pugh, K.R., Skudlarski, P., Krystal, J.H. Nicotine effects on brain function and functional connectivity in schizophrenia, Biological Psychiatry, in press.

King, S.L., Caldarone, B.J. & Picciotto, M.R. Reduced anxiety-like behavior in mice lacking b2 subunit containing nAChRs. Pharmacology, Biochemistry & Behavior, under revision.

McKee, S. A., Rounsaville, D., Petrelli, P. & Hinson, R. E. (in press). Subjective effects of smoking while drinking among college students. Nicotine and Tobacco Research.

Olausson, P., Jentsch, J.D., & Taylor, J.R. (2004). Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization. Psychopharmacology, accepted pending revision.

Potenza, M.N., Steinberg, M. A., McLaughlin, S. D., Wu, R., Rounsaville, B. J., Krishnan-Sarin, S., George, T.P., & O'Malley, S. S. (in press). Characteristics of tobacco-smoking problem gamblers calling a gambling helpline. American Journal of Addictions.

Sacco, K.A., Bannon, K.L., George, T.P. (2004). Nicotinic Receptor Mechanisms and Cognitive Function in Normal States and Neuropsychiatric Disorders. J. Psychopharmacol., in press.

Salovey, P., & Williams-Piehota, P. (in press). Field experiments in social psychology: Message framing and the promotion of health protective behaviors. American Behavioral Scientist.

Salovey, P. (in press). Promoting prevention and detection: Psychologically tailoring and framing messages about health. In R. Bibace, J. Laird, K.D. Noller, & J. Valsiner (Eds.), Science and medicine in dialogue: Thinking through particulars and universals. Westport, CT: Greenwood Publishing.

Snyder, A., Falba, T.A., Busch, S.A., & Sindelar, J. (in press). Are state legislatures responding to public opinion when allocating funds for tobacco control programs? Special issue: The Shifting Landscape: Tobacco Control and Prevention Five Years after the Master Settlement Agreement" forthcoming Health Promotion Practice (2004).

Steward, W. T., Schneider, T. R., Pizarro, J. & Salovey, P. (in press). Need for cognition moderates responses to framed smoking cessation messages. Journal of Applied Social Psychology.

 

 
   
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